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I don't have much native blood in me at all, but I do have strange reactions to medications.
Back when I had really bad insomnia, I tried sleeping pills, and guess what? After 15 minutes of drowsiness, I was hyper as heck for the rest of the night.
As for pain...I'm not a big pain pill taker but when I have to take some, the lower dosage never works.
(kinda OT):
Your post kinda reminds me of the studies they did with religious mystics/gurus/monks - they gave some of them LSD (normal dosage for the average person) and most of them just sat there like, "Um, is something supposed to happen yet? I'm bored and have a headache", but that was it. No tripping, nothing.
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